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JSH Guidelines for the Management of Hepatitis B Virus Infection

Drafting Committee for Hepatitis Management Guidelines and the Japan Societyof Hepatology
Hepatology Research 2014; 44 (Suppl. 1): 1–58
Número: 2906 / Publicado em 06/03/2015 - 16:03

It is estimated that there are 400 million patients of persistent hepatitis B virus (HBV) infection in the world. In Japan, the HBV infection rate is around 1%. HBV infection at birth or during infancy leads to persistent infection in over 90% of cases. Approximately 90% of these undergo seroconversion from HBe antigen (HBeAg) positive at the initial stage to anti-HBe antibody positive and become inactive carriers, and in virtually all cases the condition effectively stabilizes. But in the remaining 10% the virus remains active, leading to chronic hepatitis, and in around 2% of cases annually, there is further progression to liver cirrhosis, with potential for hepatocellular carcinoma (HCC) and liver failure.

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A Nomogram for Calculating the Maximum Dose of Local Anaesthetic

D. J. Williams and J. D. Walker
Anaesthesia 2014, 69, 847–853
Número: 2905 / Publicado em 06/03/2015 - 15:53

Toxic dose limits ( for local anaesthetics based on body weight are well-established, but calculation of the maximum safe volume (ml) of a given agent and formulation is complex, and frequently results in errors. We therefore developed a nomogram to perform this calculation. We compared the performance of the nomogram with a spread sheet and a general purpose calculator using simulated clinical data.

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International Consensus on Drug Allergy

Demoly et al.
Allergy 69 (2014) 420–437 © 2014
Número: 2904 / Publicado em 06/03/2015 - 15:46

When drug reactions resembling allergy occur, they are called drug hypersensitivity reactions (DHRs) before showing the evidence of either drug-specific antibodies or T cells. DHRs may be allergic or nonallergic in nature, with drug allergies being immunologically mediated DHRs. These reactions are typically unpredictable. They can be life-threatening, may require or prolong hospitalization, and may necessitate changes in subsequent therapy. Both under diagnosis (due to under-reporting) and over diagnosis (due to an overuse of the term ‘allergy’) are common.

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Primary Prevention of Food Allergy in Children and Adults: Systematic Review

de Silva et al.
Allergy 69 (2014) 581–589 © 2014
Número: 2903 / Publicado em 06/03/2015 - 15:42

Food allergies can have serious physical, social, and financial consequences. This systematic review examined ways to prevent the development of food allergy in children and adults.

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Revised U.K. Guidelines for the Management of Cutaneous Melanoma 2010

J.R. Mars den, J.A. Newton-Bishop, L. Burrows, M. Cook, P.G. Corrie, N.H. Cox, M.E. Gore, P. Lorigan, R. MacKie, P. Nathan, H. Peach, B. Powell and C. Walker
British Journal of Dermatology 2010 163, pp238–256
Número: 2902 / Publicado em 06/03/2015 - 15:36

These guidelines for the management of cutaneous melanoma present evidence-based guidance for treatment, with identification of the strength of evidence available at the time of preparation of the guidelines, and a brief overview of epidemiology, diagnosis, investigation and follow up.

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Antidrug Antibodies in Psoriasis: a Systematic Review

L. Hsu, B.T. Snodgrass and A.W. Armstrong
British Journal of Dermatology (2014) 170 , pp261–273
Número: 2901 / Publicado em 02/04/2015 - 08:21

Antidrug antibodies (ADAs) against biological agents may be clinically significant and potentially alter a biological drug’s treatment efficacy. This systematic review aims to (i) determine the prevalence of ADAs against infliximab, etanercept, adalimumab and ustekinumab in patients with psoriasis; (ii) ascertain whether ADAs are associated with changes in drug efficacy; and (iii) explore the use of concomitant methotrexate to prevent ADA formation.

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Consenso Bariátrico

João Batista Marchesini e Irineu Rasera Jr
Sociedade Brasileira de Cirurgia Bariátrica e Metabólica (SBCBM)
Número: 2900 / Publicado em 06/03/2015 - 15:11

Este consenso entende que os demais procedimentos e técnicas cirúrgicas para o controle da obesidade não relacionadas neste documento não apresentam indicação atual de utilização ou se encontram em fase de estudos, sem apresentar até o momento documentação científica consistente que permitam sua realização fora de protocolos de pesquisa devidamente regulamentados pelo Conselho Nacional de Ética em Pesquisa (CONEP), em conformidade com a Resolução 196 de 1996 do Conselho Nacional de Saúde ou outra que venha substituí-la ou complementá-la.

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Acute Coronary Syndromes: Initial Medical Therapy Guideline

Guideline 14.2 - July 2012
Australian Resuscitation Council
Número: 2899 / Publicado em 06/03/2015 - 14:26

There are a number of therapies in patients with Acute Coronary Sydnromes (ACS) that provide relief for symptoms.

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Standards of Medical Care in Diabetes - 2015: Summary of Revisions

American Diabetes Association
Diabetes Care 2015;38 (Suppl. 1)
Número: 2898 / Publicado em 06/03/2015 - 13:58

Whereas the “Standards of Medical Care in Diabetes - 2015” should still be viewed as a single document, it has been divided into 14 sections, each individually referenced, to highlight important topic areas and to facilitate navigation. The supplement now includes an index to help readers find information on particular topics.

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Definition and Diagnosis of Diabetes mellitus and Intermediate Hyperglycemia

International Diabetes Federation
World Health Organization 2006
Número: 2896 / Publicado em 06/03/2015 - 13:44

Recent estimates indicate there were 171 million people in the world with diabetes in the year 2000 and this is projected to increase to 366 million by 2030­. Diabetes is a condition primarily defined by the level of hyperglycaemia giving rise to risk of microvascular damage (retinopathy, nephropathy and neuropathy). It is associated with reduced life expectancy, significant morbidity due to specific diabetes related microvascular complications, increased risk of macrovascular complications (ischaemic heart disease, stroke and peripheral vascular disease), and diminished quality of life.

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